The Business Continuity Plan articulates a strategy to secure a long-term funding mechanism, beyond time-limited grants which will be essential for the translational benefits of health genomics to be achieved (e.g. acute care genomics, newborn screening, pharmacogenomics, novel precision therapies). The options available to Australian Genomics are evaluated and a way forward is proposed. This Business Continuity Plan is for submission to NHMRC and the Department of Health for approval under Section 10.5 of the Australian Genomics Grant Program grant guidelines.